MGME1

Across TCGA patient cohorts, MGME1 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGME1-associated genes across cancer lineages are MIR98, LINC00533, and HS6ST2-AS1. Each is linked with MGME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGME1-to-partner and partner-to-MGME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR98 grouped by MGME1-low versus MGME1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGME1→partner) and Y-score (partner→MGME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR98 →	+0.317	+2.631	<.001	.007	3	2
CESC	LINC00533 →	+0.141	+4.969	.002	.004	3	1
CESC	HS6ST2-AS1 →	+0.157	+4.193	<.001	.009	3	1
CESC	RN7SL201P →	+0.174	+5.569	<.001	.002	3	1
CESC	RPL12P22 →	+0.064	+5.569	<.001	.002	3	1
CESC	MIR1273H →	+0.316	+4.539	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

MIR98 by MGME1 expression — UCEC

Explore this box plot interactively →