MGME1

Across TCGA patient cohorts, MGME1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGME1-associated genes across cancer lineages are Cyclin-B1, JNK_pT183_Y185, and Ku80. Each is linked with MGME1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGME1-to-partner and partner-to-MGME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MGME1-low versus MGME1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGME1→partner) and Y-score (partner→MGME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.730	+3.000	.013	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.197	-3.169	.025	.019	3	1
UCEC	Ku80 →	+0.285	+3.335	.021	.005	3	1
UCEC	ATM →	-0.551	-3.321	.020	.010	3	1
UCEC	MEK1_p_S217_S221 →	-0.456	-3.321	.001	.010	2	1
UCEC	p38-MAPK_pT180_Y182 →	-0.735	-3.000	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Cyclin-B1 by MGME1 expression — UCEC

Explore this box plot interactively →