MGME1

Across TCGA cell cohorts, MGME1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,992 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGME1-associated GO terms across cancer lineages are DNA-templated DNA replication, Negative regulation of G2/M transition of mitotic cell cycle, and Negative regulation of cell cycle G2/M phase transition. Each is linked with MGME1 in more than 11 cancer types. Because this analysis shows association rather than direction, both MGME1-to-partner and partner-to-MGME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by MGME1-low versus MGME1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MGME1→partner) and Y-score (partner→MGME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNA-templated DNA replication →	+0.093	+0.750	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of G2/M transition of mitotic cell cycle →	+0.061	+0.486	<.001	<.001	3	12
SOFT_TISSUE	Negative regulation of cell cycle G2/M phase transition →	+0.057	+0.486	<.001	<.001	3	12
SOFT_TISSUE	Mitotic DNA replication →	+0.169	+0.857	<.001	<.001	3	12
SOFT_TISSUE	Nuclear DNA replication →	+0.116	+0.546	<.001	<.001	3	12
OVARY	Protein localization to chromosome →	+0.100	+0.869	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,992 associations by consensus.

DNA-templated DNA replication by MGME1 expression — BLOOD_Lymphoma

Explore this box plot interactively →