MGLL

Across TCGA patient cohorts, MGLL protein abundance is significantly associated with the RNA expression of many other genes, with 13,453 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MGLL-associated genes across cancer lineages are CHEK2, EXO1, and SPAG5. Each is linked with MGLL in more than 6 cancer types. Because this analysis shows association rather than direction, both MGLL-to-partner and partner-to-MGLL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MGLL versus CHEK2 in LSCC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGLL→partner) and Y-score (partner→MGLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHEK2 →	-0.754	-0.439	<.001	<.001	3	7
LSCC	EXO1 →	-0.969	-0.470	<.001	<.001	3	6
LUAD	SPAG5 →	-0.837	-0.343	<.001	<.001	3	6
LSCC	CENPI →	-0.818	-0.481	<.001	<.001	3	5
LSCC	CDCA3 →	-0.836	-0.563	<.001	<.001	3	5
LSCC	CACYBP →	-0.753	-0.465	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,453 associations by consensus.

MGLL vs CHEK2 — LSCC

Explore this scatter interactively →