MGLL

Across TCGA patient cohorts, MGLL mutation is significantly associated with the RNA expression of many other genes, with 3,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGLL-associated genes across cancer lineages are SAAL1, MCRIP2, and RPS19BP1. Each is linked with MGLL in more than 1 cancer types. Because this analysis shows association rather than direction, both MGLL-to-partner and partner-to-MGLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAAL1 grouped by MGLL-low versus MGLL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGLL→partner) and Y-score (partner→MGLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SAAL1 →	+0.477	+3.331	.008	.005	3	2
SKCM	MCRIP2 →	+0.534	+3.359	.007	.005	3	2
SKCM	RPS19BP1 →	+0.445	+3.208	.003	.009	3	2
SKCM	RANBP1P1 →	+0.436	+2.719	.004	.003	3	2
SKCM	DDT →	+0.556	+2.623	.001	.005	3	2
UCEC	PAQR4 →	+0.647	+2.923	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,117 associations by consensus.

SAAL1 by MGLL expression — SKCM

Explore this box plot interactively →