MGLL

Across TCGA patient cohorts, MGLL mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGLL-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, mTOR_pS2448, and PCNA. Each is linked with MGLL in more than 1 cancer types. Because this analysis shows association rather than direction, both MGLL-to-partner and partner-to-MGLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by MGLL-low versus MGLL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGLL→partner) and Y-score (partner→MGLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.467	+2.321	.010	.001	3	2
UCEC	mTOR_pS2448 →	-0.195	-2.395	<.001	.003	3	2
UCEC	PCNA →	+0.246	+1.925	.001	.005	3	2
UCEC	TFRC →	+0.459	+1.925	.016	.005	3	2
SKCM	HER2_pY1248 →	-0.141	-2.459	.043	.020	3	1
SKCM	PI3K-p110-a →	+0.153	+3.000	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Acetyl-a-Tubulin-Lys40 by MGLL expression — UCEC

Explore this box plot interactively →