MGLL

Across TCGA cell cohorts, MGLL mutation is significantly associated with the mutation status of many other genes, with 5,306 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MGLL-associated genes across cancer lineages are FCHSD2, PAK5, and RINT1. Each is linked with MGLL in more than 2 cancer types. Because this analysis shows association rather than direction, both MGLL-to-partner and partner-to-MGLL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCHSD2 grouped by MGLL-low versus MGLL-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGLL→partner) and Y-score (partner→MGLL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	FCHSD2 →	+3.930	+3.632	.003	.003	1	3
LUNG_NSCLC_LUAD	PAK5 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	RINT1 →	+5.000	+4.187	.008	.008	1	3
LUNG_NSCLC_LUAD	DNALI1 →	+5.000	+4.187	.008	.008	1	3
LUNG_NSCLC_LUAD	OTOP1 →	+3.584	+4.063	.003	.003	1	3
LUNG_NSCLC_LUAD	USP48 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,306 associations by consensus.

FCHSD2 by MGLL expression — OVARY

Explore this box plot interactively →