MGAT5B

Across TCGA pan-cancer cohorts, MGAT5B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MGAT5B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MGAT5B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MGAT5B is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, BRCA, and THCA are the cancer types where MGAT5B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGAT5B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.777	<.001	11	view →
BRCA	Female	II,III,IV	+0.470	<.001	6	view →
THCA	Male	III,IV	−0.302	.002	4	view →
COAD	All	III,IV	−0.162	.002	4	view →
KICH	Female	All	−0.340	.003	3	view →
PRAD	All	All	+0.408	<.001	2	view →
READ	Female	All	−0.286	.003	2	view →
PAAD	Male	All	−0.229	.022	2	view →
LIHC	All	All	+0.082	.007	2	view →
LUAD	Male	II,III,IV	+1.120	.015	1	view →
ESCA	Female	All	−0.246	.008	1	view →
BLCA	Female	IV	−0.146	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MGAT5B–HNSC

Open the HNSC breakdown →