MGAT5

Across TCGA patient cohorts, MGAT5 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT5-associated genes across cancer lineages are STAT3_pY705, C-Raf, and Caspase-7-cleavedD198. Each is linked with MGAT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAT5-to-partner and partner-to-MGAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by MGAT5-low versus MGAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT5→partner) and Y-score (partner→MGAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.399	-1.906	<.001	.014	3	3
COAD	C-Raf →	+0.153	+3.008	.043	.019	3	3
UCEC	Caspase-7-cleavedD198 →	+0.696	+1.926	.001	.008	3	3
COAD	p62 Lck ligand →	+0.434	+3.008	.030	.019	3	2
UCEC	Notch1 →	+0.119	+1.598	.019	.040	3	2
COAD	FASN →	+0.473	+3.008	.019	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

STAT3_pY705 by MGAT5 expression — UCEC

Explore this box plot interactively →