MGAT5

Across TCGA cell cohorts, MGAT5 mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MGAT5-associated genes across cancer lineages are DEFA6, OR10Q1, and OR52B4. Each is linked with MGAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT5-to-partner and partner-to-MGAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by MGAT5-low versus MGAT5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT5→partner) and Y-score (partner→MGAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFA6 →	+0.972	+4.044	<.001	.009	3	1
LUNG_SCLC	OR10Q1 →	+0.490	+4.643	<.001	.004	3	1
LUNG_SCLC	OR52B4 →	+0.017	+4.643	<.001	.004	3	1
BLOOD_Leukemia	RTL4 →	+0.018	+4.567	.001	.001	3	1
BLOOD_Leukemia	VWC2 →	+0.379	+3.551	<.001	.009	3	1
OVARY	MTRNR2L10 →	+0.006	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

DEFA6 by MGAT5 expression — LUNG_SCLC

Explore this box plot interactively →