MGAT4A

Across TCGA patient cohorts, MGAT4A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT4A-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and GAPDH. Each is linked with MGAT4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT4A-to-partner and partner-to-MGAT4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MGAT4A-low versus MGAT4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT4A→partner) and Y-score (partner→MGAT4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-3.906	.001	<.001	3	2
UCEC	eIF4E →	+0.188	+3.335	.011	.005	3	2
UCEC	GAPDH →	+0.504	+3.459	.007	.005	3	2
UCEC	MEK1 →	+0.407	+3.000	.001	<.001	3	2
UCEC	PDCD4 →	-0.662	-2.492	<.001	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.266	-1.662	.006	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

EGFR_pY1068 by MGAT4A expression — UCEC

Explore this box plot interactively →