MGAT3

Across TCGA cell cohorts, MGAT3 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGAT3-associated genes across cancer lineages are PROP1, GFRA4, and NPSR1. Each is linked with MGAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT3-to-partner and partner-to-MGAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by MGAT3-low versus MGAT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT3→partner) and Y-score (partner→MGAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PROP1 →	+0.026	+2.791	<.001	.005	3	2
BLOOD_Leukemia	GFRA4 →	+0.314	+4.409	<.001	.005	3	2
BLOOD_Leukemia	NPSR1 →	+0.028	+4.152	<.001	.009	3	2
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LARGE_INTESTINE	TKTL2 →	+0.035	+4.187	.003	.002	3	1
LARGE_INTESTINE	ADH1A →	+0.143	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PROP1 by MGAT3 expression — LARGE_INTESTINE

Explore this box plot interactively →