MGAT2

Across TCGA patient cohorts, MGAT2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT2-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Ku80. Each is linked with MGAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT2-to-partner and partner-to-MGAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MGAT2-low versus MGAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT2→partner) and Y-score (partner→MGAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.139	-2.074	<.001	.005	3	1
UCEC	JNK2 →	+0.255	+2.087	<.001	.005	3	1
UCEC	Ku80 →	+0.365	+3.713	<.001	<.001	3	1
UCEC	MEK1 →	+0.458	+3.906	.001	<.001	3	1
UCEC	MSH2 →	-0.272	-1.973	.002	.029	3	1
UCEC	Notch1 →	+0.151	+1.750	.005	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

14-3-3_beta by MGAT2 expression — UCEC

Explore this box plot interactively →