MGAT1

Across TCGA pan-cancer cohorts, MGAT1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MGAT1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MGAT1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MGAT1 is over-expressed in tumor.

CCRCC, COAD, and HNSC are the cancer types where MGAT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGAT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	IV	+1.018	<.001	12	view →
COAD	Male	II,III,IV	+0.228	<.001	10	view →
HNSC	All	All	+0.231	<.001	8	view →
PDAC	Female	III,IV	+0.742	.010	4	view →
LSCC	Female	III,IV	+0.213	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MGAT1–CCRCC

Open the CCRCC breakdown →