MGAT1

Across TCGA patient cohorts, MGAT1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT1-associated genes across cancer lineages are MEK1, 4E-BP1, and Cyclin-B1. Each is linked with MGAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT1-to-partner and partner-to-MGAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MGAT1-low versus MGAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT1→partner) and Y-score (partner→MGAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.406	+2.700	.005	.006	3	2
UCEC	4E-BP1 →	+0.384	+2.415	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.668	+2.415	.003	.003	3	2
COAD	Lck →	+0.394	+3.195	.008	.010	3	1
UCEC	14-3-3_beta →	-0.130	-3.432	.001	.005	3	1
UCEC	eIF4E →	+0.203	+2.584	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by MGAT1 expression — UCEC

Explore this box plot interactively →