MGAT1

Across TCGA cell cohorts, MGAT1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGAT1-associated genes across cancer lineages are TAS2R39, OR2T35, and OR2M4. Each is linked with MGAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MGAT1-to-partner and partner-to-MGAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by MGAT1-low versus MGAT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT1→partner) and Y-score (partner→MGAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAS2R39 →	+0.048	+4.661	<.001	<.001	3	2
PANCREAS	OR2T35 →	+0.015	+4.614	<.001	.004	3	1
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	1
OVARY	PROP1 →	+0.023	+4.228	<.001	.006	3	1
OVARY	OR2H1 →	+0.019	+4.029	.003	.009	3	1
OVARY	OR2L8 →	+0.038	+4.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TAS2R39 by MGAT1 expression — BLOOD_Leukemia

Explore this box plot interactively →