MGARP

Across TCGA patient cohorts, MGARP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGARP-associated genes across cancer lineages are EGFR, GSK-3a-b_pS21_S9, and Tuberin_pT1462. Each is linked with MGARP in more than 1 cancer types. Because this analysis shows association rather than direction, both MGARP-to-partner and partner-to-MGARP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by MGARP-low versus MGARP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGARP→partner) and Y-score (partner→MGARP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.273	-3.000	.003	.037	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.603	+2.817	.014	.036	3	1
UCEC	Tuberin_pT1462 →	+0.410	+3.009	.002	.019	3	1
UCEC	Bax →	+0.275	+3.000	.047	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.717	+2.827	.036	.035	3	1
UCEC	Di-Ras3 →	-0.225	-3.000	.008	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR by MGARP expression — UCEC

Explore this box plot interactively →