MFSD8

Across TCGA patient cohorts, MFSD8 protein abundance is significantly associated with the protein abundance of many other proteins, with 1,680 significant associations in total. OV shows the largest number of these associations.

The most reproducible MFSD8-associated proteins across cancer lineages are FZD6_S653, HACL1_S192, and HDGFL3_T203. Each is linked with MFSD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD8-to-partner and partner-to-MFSD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MFSD8 versus FZD6_S653 in LUAD, with a Pearson correlation of 0.62.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD8→partner) and Y-score (partner→MFSD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FZD6_S653 →	+1.065	+0.739	<.001	<.001	3	2
LUAD	HACL1_S192 →	-0.440	-0.347	.004	.004	3	1
LUAD	HDGFL3_T203 →	-0.608	-0.907	<.001	.001	3	1
LUAD	ANAPC5 →	-0.176	-0.594	.002	.002	3	1
LUAD	IGHV3-35 →	-0.483	-0.471	.003	.001	3	1
LUAD	IGLV4-69 →	-1.189	-0.562	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,680 associations by consensus.

MFSD8 vs FZD6_S653 — LUAD

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