MFSD8

Across TCGA patient cohorts, MFSD8 mutation is significantly associated with the RNA expression of many other genes, with 2,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD8-associated genes across cancer lineages are MIR548AI, SC4MOP, and LINC01941. Each is linked with MFSD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD8-to-partner and partner-to-MFSD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AI grouped by MFSD8-low versus MFSD8-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD8→partner) and Y-score (partner→MFSD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AI →	+0.182	+8.057	<.001	.005	3	2
HNSC	SC4MOP →	+0.038	+4.505	<.001	.009	3	2
CESC	LINC01941 →	+0.145	+6.254	<.001	<.001	3	2
UCEC	ZNF367 →	+0.754	+2.321	.001	.006	3	2
UCEC	MAP2K1 →	+0.657	+2.839	<.001	.001	3	2
UCEC	SPATA5L1 →	+0.526	+3.657	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,170 associations by consensus.

MIR548AI by MFSD8 expression — BRCA

Explore this box plot interactively →