MFSD8

Across TCGA patient cohorts, MFSD8 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD8-associated genes across cancer lineages are eIF4E, C-Raf, and EGFR_pY1068. Each is linked with MFSD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD8-to-partner and partner-to-MFSD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MFSD8-low versus MFSD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD8→partner) and Y-score (partner→MFSD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.213	+2.700	.025	.006	3	2
UCEC	C-Raf →	+0.170	+2.000	.008	.032	3	2
UCEC	EGFR_pY1068 →	-0.299	-2.700	.008	.006	3	1
UCEC	HER2_pY1248 →	-0.244	-3.807	.043	<.001	3	1
UCEC	IGFBP2 →	-0.848	-2.000	.003	.032	3	1
UCEC	MEK1 →	+0.451	+3.459	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by MFSD8 expression — UCEC

Explore this box plot interactively →