MFSD6

Across TCGA pan-cancer cohorts, MFSD6 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MFSD6 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MFSD6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MFSD6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where MFSD6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.978	0.766	.011	22	view →
HNSC	OS	Median	III,IV	0.943	1.000	.034	19	view →
PDAC	DFS	Tertile	III,IV	0.872	0.216	.024	10	view →
OV	DFS	Quartile	All	0.472	1.000	.014	8	view →
LUAD	DFS	Quartile	II,III,IV	0.204	0.677	.016	8	view →
LSCC	DFS	Tertile	II,III,IV	0.498	1.000	.040	2	view →
GBM	DFS	Tertile	All	0.841	0.595	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MFSD6–UCEC (OS)

Open the UCEC breakdown →