MFSD6

Across TCGA patient cohorts, MFSD6 mutation is significantly associated with the RNA expression of many other genes, with 4,528 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD6-associated genes across cancer lineages are FAM230A, H3P11, and RNA5SP436. Each is linked with MFSD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD6-to-partner and partner-to-MFSD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM230A grouped by MFSD6-low versus MFSD6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD6→partner) and Y-score (partner→MFSD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM230A →	+0.014	+6.038	<.001	.001	3	2
LIHC	H3P11 →	+0.117	+5.186	.001	.007	3	2
UCEC	RNA5SP436 →	+0.175	+2.215	<.001	.004	3	2
UCEC	RPL31P40 →	+0.172	+1.592	.007	.001	3	2
LUAD	OR6B2 →	+0.033	+4.491	<.001	<.001	3	2
LUAD	MTND4P30 →	+0.139	+3.468	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,528 associations by consensus.

FAM230A by MFSD6 expression — BRCA

Explore this box plot interactively →