MFSD6

Across TCGA cell cohorts, MFSD6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFSD6-associated genes across cancer lineages are CALHM4, PROP1, and TEX43. Each is linked with MFSD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD6-to-partner and partner-to-MFSD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by MFSD6-low versus MFSD6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD6→partner) and Y-score (partner→MFSD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	PROP1 →	+0.032	+4.874	<.001	.002	3	1
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.011	+4.874	<.001	.002	3	1
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	1
BREAST	KRTAP10-1 →	+0.019	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CALHM4 by MFSD6 expression — BLOOD_Leukemia

Explore this box plot interactively →