MFSD5

Across TCGA pan-cancer cohorts, MFSD5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MFSD5 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MFSD5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFSD5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where MFSD5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.674	1.000	.013	8	view →
HNSC	DFS	Tertile	All	1.000	0.737	.049	6	view →
LSCC	DFS	Quartile	All	0.641	0.917	.020	6	view →
OV	DFS	Median	All	0.913	0.560	.047	4	view →
CCRCC	DFS	Median	II,III,IV	0.308	1.000	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MFSD5–LUAD (DFS)

Open the LUAD breakdown →