MFSD4A

Across TCGA pan-cancer cohorts, MFSD4A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MFSD4A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MFSD4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MFSD4A is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LUAD, and PDAC are the cancer types where MFSD4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MFSD4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−2.761	<.001	11	view →
LUAD	Male	II,III,IV	+1.134	<.001	8	view →
PDAC	All	III,IV	+2.092	<.001	6	view →
LSCC	Female	II,III,IV	−2.225	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MFSD4A–CCRCC

Open the CCRCC breakdown →