MFSD2A

Across TCGA patient cohorts, MFSD2A mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD2A-associated genes across cancer lineages are FASN, MEK1, and PR. Each is linked with MFSD2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD2A-to-partner and partner-to-MFSD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MFSD2A-low versus MFSD2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD2A→partner) and Y-score (partner→MFSD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.462	+2.584	.003	.010	3	2
UCEC	MEK1 →	+0.479	+2.807	.001	.003	3	2
UCEC	PR →	-0.253	-3.321	.012	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.818	+3.700	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.801	+3.087	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.113	-2.432	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FASN by MFSD2A expression — UCEC

Explore this box plot interactively →