MFSD2A

Across TCGA cell cohorts, MFSD2A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MFSD2A-associated genes across cancer lineages are OPALIN, ZNF831, and RNASE2. Each is linked with MFSD2A in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD2A-to-partner and partner-to-MFSD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPALIN grouped by MFSD2A-low versus MFSD2A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD2A→partner) and Y-score (partner→MFSD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OPALIN →	+0.072	+4.977	<.001	.007	3	2
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	RNASE2 →	+0.239	+3.491	<.001	.008	3	1
LARGE_INTESTINE	ODF3 →	+0.036	+3.836	.001	.003	3	1
LARGE_INTESTINE	FOXI2 →	+0.013	+3.217	<.001	.006	3	1
SKIN	OR8K3 →	+0.073	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OPALIN by MFSD2A expression — SKIN

Explore this box plot interactively →