MFSD14B

Across TCGA patient cohorts, MFSD14B mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD14B-associated genes across cancer lineages are Heregulin, IGFBP2, and JNK2. Each is linked with MFSD14B in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD14B-to-partner and partner-to-MFSD14B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by MFSD14B-low versus MFSD14B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD14B→partner) and Y-score (partner→MFSD14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.127	-2.321	.007	.005	3	1
UCEC	IGFBP2 →	-0.736	-2.459	.003	.018	3	1
UCEC	JNK2 →	+0.189	+2.026	.013	.016	3	1
UCEC	Ku80 →	+0.212	+1.691	.019	.014	3	1
UCEC	MEK1 →	+0.446	+3.000	.001	<.001	3	1
UCEC	Notch1 →	+0.138	+1.884	.010	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Heregulin by MFSD14B expression — UCEC

Explore this box plot interactively →