MFSD14B

Across TCGA cell cohorts, MFSD14B mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MFSD14B-associated genes across cancer lineages are FGF23, LMNTD1, and FANCD2OS. Each is linked with MFSD14B in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD14B-to-partner and partner-to-MFSD14B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF23 grouped by MFSD14B-low versus MFSD14B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD14B→partner) and Y-score (partner→MFSD14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FGF23 →	+0.482	+3.584	<.001	.003	2	2
LARGE_INTESTINE	LMNTD1 →	+0.133	+2.969	<.001	.007	3	1
LARGE_INTESTINE	FANCD2OS →	+0.159	+3.667	<.001	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.010	+3.217	.002	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.230	+3.103	.002	.004	3	1
LARGE_INTESTINE	ANKRD63 →	+0.298	+3.963	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FGF23 by MFSD14B expression — LARGE_INTESTINE

Explore this box plot interactively →