MFSD10

Across TCGA patient cohorts, MFSD10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD10-associated genes across cancer lineages are Rad50, Beclin, and Caspase-7-cleavedD198. Each is linked with MFSD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD10-to-partner and partner-to-MFSD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MFSD10-low versus MFSD10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD10→partner) and Y-score (partner→MFSD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.391	-3.459	.001	.005	3	1
UCEC	Beclin →	+0.096	+2.321	.043	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.642	+2.827	.031	.035	3	1
UCEC	CDK1 →	-0.162	-2.321	.033	.035	3	1
UCEC	4E-BP1_pS65 →	-0.251	-2.308	.010	.036	2	1
UCEC	Src →	+0.236	+3.459	.022	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rad50 by MFSD10 expression — UCEC

Explore this box plot interactively →