MFSD1

Across TCGA patient cohorts, MFSD1 mutation is significantly associated with the RNA expression of many other genes, with 1,367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD1-associated genes across cancer lineages are PDCD1, RNA5SP260, and IGLV3-19. Each is linked with MFSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD1-to-partner and partner-to-MFSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD1 grouped by MFSD1-low versus MFSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD1→partner) and Y-score (partner→MFSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD1 →	+0.745	+3.609	.005	.001	3	2
UCEC	RNA5SP260 →	+0.478	+1.896	<.001	.002	3	2
UCEC	IGLV3-19 →	+1.622	+2.415	.005	.003	3	2
READ	APOOP2 →	+0.655	+5.039	<.001	.008	3	2
UCEC	AOC2 →	+1.036	+2.828	<.001	<.001	3	2
UCEC	CXCL9 →	+2.036	+4.255	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,367 associations by consensus.

PDCD1 by MFSD1 expression — UCEC

Explore this box plot interactively →