MFSD1

Across TCGA patient cohorts, MFSD1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD1-associated genes across cancer lineages are p27_pT198, TFRC, and ATM. Each is linked with MFSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD1-to-partner and partner-to-MFSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by MFSD1-low versus MFSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD1→partner) and Y-score (partner→MFSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.091	+1.765	.023	.014	3	2
UCEC	TFRC →	+0.418	+3.000	.035	.036	3	2
UCEC	ATM →	-0.601	-2.169	<.001	.003	3	2
UCEC	c-Kit →	-0.191	-2.169	.029	.003	3	2
UCEC	ERK2 →	+0.163	+3.459	.024	.005	3	1
UCEC	ACC_pS79 →	+0.316	+2.009	.015	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p27_pT198 by MFSD1 expression — UCEC

Explore this box plot interactively →