MFNG

Across TCGA patient cohorts, MFNG mutation is significantly associated with the RNA expression of many other genes, with 2,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFNG-associated genes across cancer lineages are CTNNB1, CDCA4, and SETD3. Each is linked with MFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both MFNG-to-partner and partner-to-MFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTNNB1 grouped by MFNG-low versus MFNG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFNG→partner) and Y-score (partner→MFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CTNNB1 →	+0.832	+2.629	.003	.005	3	2
UCEC	CDCA4 →	+0.557	+3.000	.002	.001	3	2
SKCM	SETD3 →	+0.518	+2.629	.001	.005	3	2
SKCM	BTBD6 →	+0.579	+2.591	.001	.006	3	2
SKCM	RNA5SP109 →	+0.066	+4.225	<.001	.005	3	2
SKCM	OR5M2P →	+0.357	+4.006	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,531 associations by consensus.

CTNNB1 by MFNG expression — SKCM

Explore this box plot interactively →