MFNG

Across TCGA cell cohorts, MFNG mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible MFNG-associated genes across cancer lineages are ZSCAN1, TBL1Y, and USP17L7. Each is linked with MFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both MFNG-to-partner and partner-to-MFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN1 grouped by MFNG-low versus MFNG-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFNG→partner) and Y-score (partner→MFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
LARGE_INTESTINE	USP17L7 →	+0.100	+3.691	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ZSCAN1 by MFNG expression — PANCREAS

Explore this box plot interactively →