MFN2

Across TCGA patient cohorts, MFN2 mutation is significantly associated with the RNA expression of many other genes, with 2,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFN2-associated genes across cancer lineages are RN7SL134P, RN7SKP46, and RNU6-618P. Each is linked with MFN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MFN2-to-partner and partner-to-MFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by MFN2-low versus MFN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN2→partner) and Y-score (partner→MFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.132	+2.207	<.001	<.001	3	3
BLCA	RN7SKP46 →	+0.152	+5.307	<.001	.001	3	2
CESC	RNU6-618P →	+0.513	+5.201	<.001	.007	3	2
LUSC	RNU6-114P →	+0.454	+5.404	<.001	.005	3	2
LUAD	RBM22P3 →	+0.030	+4.584	<.001	.005	3	2
LUAD	CYCSP11 →	+0.248	+4.636	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,814 associations by consensus.

RN7SL134P by MFN2 expression — UCEC

Explore this box plot interactively →