MFN2

Across TCGA patient cohorts, MFN2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFN2-associated genes across cancer lineages are 4E-BP1, C-Raf, and JNK2. Each is linked with MFN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFN2-to-partner and partner-to-MFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MFN2-low versus MFN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN2→partner) and Y-score (partner→MFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.273	+2.145	.007	.009	3	2
UCEC	C-Raf →	+0.162	+2.169	.002	.003	3	2
UCEC	JNK2 →	+0.196	+1.763	.008	.048	3	1
UCEC	Ku80 →	+0.231	+1.778	.009	.008	3	1
UCEC	MEK1 →	+0.514	+2.807	<.001	.002	3	1
UCEC	Notch1 →	+0.197	+2.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

4E-BP1 by MFN2 expression — UCEC

Explore this box plot interactively →