MFN2

Across TCGA cell cohorts, MFN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,853 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFN2-associated GO terms across cancer lineages are Mitotic spindle elongation, Mitotic spindle midzone assembly, and Cellular response to methionine. Each is linked with MFN2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MFN2-to-partner and partner-to-MFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic spindle elongation grouped by MFN2-low versus MFN2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN2→partner) and Y-score (partner→MFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitotic spindle elongation →	+0.290	+0.872	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.290	+0.872	<.001	<.001	3	17
LUNG_SCLC	Cellular response to methionine →	+0.123	+0.558	<.001	.002	3	16
LUNG_SCLC	Response to methionine →	+0.123	+0.558	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.192	+0.932	<.001	.001	3	15
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.145	+0.696	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,853 associations by consensus.

Mitotic spindle elongation by MFN2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →