MFN1

Across TCGA pan-cancer cohorts, MFN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MFN1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MFN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFN1 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where MFN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.568	0.863	.008	52	view →
COAD	DFS	Median	All	1.000	0.919	.012	36	view →
HNSC	OS	Median	IV	0.762	0.939	.008	15	view →
GBM	DFS	Median	All	0.469	0.275	.003	15	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	DFS	Quartile	II,III,IV	0.702	0.289	.015	5	view →
LSCC	DFS	Median	III,IV	0.650	0.916	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MFN1–CCRCC (DFS)

Open the CCRCC breakdown →