MFN1

Across TCGA patient cohorts, MFN1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,471 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MFN1-associated genes across cancer lineages are DSE, RHOH, and MCTP1. Each is linked with MFN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both MFN1-to-partner and partner-to-MFN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MFN1 versus DSE in GBM, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN1→partner) and Y-score (partner→MFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DSE →	-0.718	-0.163	<.001	.004	3	7
BRCA	RHOH →	-1.148	-0.298	<.001	<.001	3	5
COAD	MCTP1 →	-0.702	-0.189	<.001	<.001	3	5
GBM	LILRB3 →	-0.954	-0.278	<.001	<.001	3	5
LSCC	ARHGDIB →	-0.818	-0.548	<.001	<.001	3	5
HNSC	MTARC1 →	+0.793	+0.299	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,471 associations by consensus.

MFN1 vs DSE — GBM

Explore this scatter interactively →