MFN1

Across TCGA patient cohorts, MFN1 mutation is significantly associated with the RNA expression of many other genes, with 2,427 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFN1-associated genes across cancer lineages are HSPD1P16, MRPL57P6, and H4C7. Each is linked with MFN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MFN1-to-partner and partner-to-MFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P16 grouped by MFN1-low versus MFN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN1→partner) and Y-score (partner→MFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HSPD1P16 →	+0.291	+3.794	.002	.001	3	3
UCEC	MRPL57P6 →	+0.086	+2.705	<.001	.003	3	3
COAD	H4C7 →	+0.239	+3.602	<.001	.003	3	2
BLCA	TRDJ4 →	+0.505	+5.033	<.001	.003	3	2
LUSC	MTCO1P56 →	+0.176	+4.993	<.001	.003	3	2
BLCA	FOXL3 →	+0.136	+5.603	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,427 associations by consensus.

HSPD1P16 by MFN1 expression — COAD

Explore this box plot interactively →