MFN1

Across TCGA patient cohorts, MFN1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFN1-associated genes across cancer lineages are EGFR, INPP4B, and Caspase-7-cleavedD198. Each is linked with MFN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MFN1-to-partner and partner-to-MFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by MFN1-low versus MFN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN1→partner) and Y-score (partner→MFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.194	-3.143	.001	.018	3	2
UCEC	INPP4B →	-0.293	-2.459	.018	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.633	+2.700	.005	.005	3	2
UCEC	Caspase-8 →	-0.238	-2.087	.013	.005	3	2
UCEC	C-Raf →	+0.216	+2.807	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.107	-3.432	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR by MFN1 expression — UCEC

Explore this box plot interactively →