MFN1

Across TCGA cell cohorts, MFN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,546 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFN1-associated GO terms across cancer lineages are Positive regulation of mitochondrial membrane potential, Maintenance of centrosome location, and Establishment of protein localization to vacuole. Each is linked with MFN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both MFN1-to-partner and partner-to-MFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitochondrial membrane potential grouped by MFN1-low versus MFN1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN1→partner) and Y-score (partner→MFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of mitochondrial membrane potential →	+0.207	+1.424	.008	<.001	3	17
OVARY	Maintenance of centrosome location →	+0.120	+0.831	<.001	<.001	3	15
OVARY	Establishment of protein localization to vacuole →	+0.062	+0.703	<.001	<.001	3	13
SOFT_TISSUE	Protein desumoylation →	+0.092	+0.523	.003	.007	3	13
LARGE_INTESTINE	Protein localization to chromosome, telomeric region →	+0.092	+0.682	<.001	<.001	3	13
LARGE_INTESTINE	Protein localization to cytoskeleton →	+0.055	+0.548	.005	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,546 associations by consensus.

Positive regulation of mitochondrial membrane potential by MFN1 expression — LUNG_NSCLC_LUSC

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