MFGE8

Across TCGA pan-cancer cohorts, MFGE8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MFGE8 data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MFGE8 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated MFGE8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC and BLCA are the cancer types where MFGE8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.933	0.457	.022	18	view →
BLCA	OS	Median	IV	0.183	0.598	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MFGE8–UCEC (OS)

Open the UCEC breakdown →