MFGE8

Across TCGA pan-cancer cohorts, MFGE8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MFGE8 data layer compared with 19 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MFGE8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFGE8 expression acts as an unfavorable survival marker.

LUAD, LSCC, and CCRCC are the cancer types where MFGE8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.222	0.797	<.001	17	view →
LSCC	OS	Tertile	II,III,IV	0.667	1.000	.009	16	view →
CCRCC	DFS	Median	II,III,IV	0.199	0.839	.011	5	view →
HNSC	OS	Tertile	IV	0.650	0.862	.019	3	view →
PDAC	DFS	Tertile	IV	0.224	0.777	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MFGE8–LUAD (DFS)

Open the LUAD breakdown →