MFGE8

Across TCGA patient cohorts, MFGE8 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFGE8-associated genes across cancer lineages are ATM, INPP4B, and ASNS. Each is linked with MFGE8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MFGE8-to-partner and partner-to-MFGE8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MFGE8-low versus MFGE8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFGE8→partner) and Y-score (partner→MFGE8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.712	-3.000	<.001	<.001	3	3
COAD	INPP4B →	-0.381	-2.313	.023	.035	3	2
COAD	ASNS →	+0.750	+3.169	<.001	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.411	+3.467	<.001	.002	3	2
UCEC	ACVRL1 →	-0.124	-2.102	.011	.016	3	2
UCEC	mTOR_pS2448 →	-0.130	-2.395	.015	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by MFGE8 expression — UCEC

Explore this box plot interactively →