MFF

Across TCGA pan-cancer cohorts, MFF Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MFF data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MFF Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFF expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, COAD, and PRAD are the cancer types where MFF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.057	0.667	<.001	15	view →
COAD	OS	Median	All	0.508	0.872	.013	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.957	0.629	.046	2	view →
SKCM	DFS	Median	II,III,IV	1.000	0.561	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MFF–ACC (DFS)

Open the ACC breakdown →