MFF

Across TCGA pan-cancer cohorts, MFF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MFF data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MFF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFF expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

CCRCC, PDAC, and COAD are the cancer types where MFF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.339	0.888	.004	32	view →
PDAC	OS	Median	All	0.304	0.508	.018	30	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.893	.028	12	view →
LSCC	DFS	Tertile	III,IV	0.448	0.867	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MFF–CCRCC (DFS)

Open the CCRCC breakdown →