MFAP4

Across TCGA pan-cancer cohorts, MFAP4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MFAP4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MFAP4 RNA is repressed in tumor relative to normal tissue. In most cancer types MFAP4 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where MFAP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MFAP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−4.606	<.001	11	view →
LUAD	Male	III,IV	−3.663	<.001	11	view →
COAD	Female	II,III,IV	−2.197	<.001	11	view →
KICH	All	III,IV	−4.682	<.001	10	view →
THCA	Male	II,III,IV	−3.896	<.001	10	view →
LUSC	Female	II,III,IV	−4.164	<.001	9	view →
KIRC	Male	II,III,IV	−2.102	<.001	9	view →
LIHC	Male	All	−2.658	<.001	8	view →
HNSC	Male	All	−1.755	<.001	8	view →
KIRP	Male	All	−2.325	<.001	7	view →
STAD	All	All	−1.505	<.001	7	view →
UCEC	All	III,IV	−4.751	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MFAP4–BLCA

Open the BLCA breakdown →