Across TCGA patient cohorts, MFAP3L mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFAP3L-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with MFAP3L in more than 1 cancer types. Because this analysis shows association rather than direction, both MFAP3L-to-partner and partner-to-MFAP3L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFAP3L→partner) and Y-score (partner→MFAP3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.543	+3.584	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.836	+3.479	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.345	-3.000	<.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.200	-2.459	<.001	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-2.575	.027	.010	3	1
UCEC	ACC1 →	+0.300	+3.013	.046	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

MFAP3L survival (RNA) · tumor vs normal (RNA) · all MFAP3L data types