MFAP3

Across TCGA patient cohorts, MFAP3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFAP3-associated genes across cancer lineages are ATM, EGFR_pY1068, and GAPDH. Each is linked with MFAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MFAP3-to-partner and partner-to-MFAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MFAP3-low versus MFAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFAP3→partner) and Y-score (partner→MFAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.517	-2.401	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.208	-2.115	.015	.017	3	2
UCEC	GAPDH →	+0.421	+1.906	.021	.015	3	2
UCEC	Akt_pT308 →	+0.543	+1.247	.011	.045	3	2
UCEC	ASNS →	+0.353	+2.000	.004	.009	3	2
UCEC	eEF2 →	+0.293	+3.321	.016	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by MFAP3 expression — UCEC

Explore this box plot interactively →